It's said that the most poisonous fugu, "Tora-fugu," is the most delicious.
Tetrodotoxin is a very potent neurotoxin and shuts down electrical signaling in nerves by binding to the pores of sodium channel proteins in nerve cell membranes. The tetrodotoxin is very stable and not affected by the heat of cooking. It does not cross the blood-brain barrier, leaving the victim fully conscious while paralyzing the remainder of the body. There is no known antidote, and treatment consists of emptying the stomach, feeding the victim activeted charcoal to bind the toxin and taking standard life-support measures to keep the victim alive until the effect of the poison has worn off.
Only specially licensed chefs are allowed to prepare and sell fugu to the public, and the consumption of the liver and ovaries is forbidden. But because small amounts of the poison give a special desired sensation on the tongue, these parts are considered the most delicious by some gourmets. Every year, a number of people die because they underestimate the amount of poison in the consumed fish parts.
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